4FGT
Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000900 | molecular_function | mRNA regulatory element binding translation repressor activity |
A | 0003729 | molecular_function | mRNA binding |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005542 | molecular_function | folic acid binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005829 | cellular_component | cytosol |
A | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0006417 | biological_process | regulation of translation |
A | 0007623 | biological_process | circadian rhythm |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0009636 | biological_process | response to toxic substance |
A | 0014070 | biological_process | response to organic cyclic compound |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0017148 | biological_process | negative regulation of translation |
A | 0019860 | biological_process | uracil metabolic process |
A | 0032259 | biological_process | methylation |
A | 0032570 | biological_process | response to progesterone |
A | 0033189 | biological_process | response to vitamin A |
A | 0034097 | biological_process | response to cytokine |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0045471 | biological_process | response to ethanol |
A | 0046653 | biological_process | tetrahydrofolate metabolic process |
A | 0046683 | biological_process | response to organophosphorus |
A | 0048589 | biological_process | developmental growth |
A | 0051216 | biological_process | cartilage development |
A | 0051384 | biological_process | response to glucocorticoid |
A | 0051593 | biological_process | response to folic acid |
A | 0060574 | biological_process | intestinal epithelial cell maturation |
A | 0071897 | biological_process | DNA biosynthetic process |
A | 0097421 | biological_process | liver regeneration |
A | 1901363 | molecular_function | heterocyclic compound binding |
A | 1990825 | molecular_function | sequence-specific mRNA binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 401 |
Chain | Residue |
A | ARG78 |
A | ARG176 |
A | ARG185 |
A | LEU189 |
A | PRO305 |
A | THR306 |
A | HOH556 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 402 |
Chain | Residue |
A | HOH563 |
A | GLU272 |
A | ARG274 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 403 |
Chain | Residue |
A | ASN183 |
A | HIS196 |
A | ARG215 |
A | SER216 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR CHAIN D OF CG PEPTIDE |
Chain | Residue |
A | PHE137 |
A | PHE142 |
A | PHE142 |
A | GLY143 |
A | ALA144 |
A | ILE178 |
A | CYS180 |
A | TRP182 |
A | TRP182 |
A | ALA191 |
A | LEU192 |
A | LEU192 |
A | PRO193 |
A | CME195 |
A | CME195 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImcaWNprdlplma.....LpPCHalcQFyV |
Chain | Residue | Details |
A | ARG175-VAL203 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
A | CME195 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: in other chain => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
A | ARG50 | |
A | ASN226 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P45352 |
Chain | Residue | Details |
A | ARG175 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: in other chain => ECO:0000250|UniProtKB:P45352 |
Chain | Residue | Details |
A | CME195 | |
A | ARG215 | |
A | HIS256 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
A | ASP218 | |
A | ALA312 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER114 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS287 | |
A | LYS292 | |
A | LYS308 |