4FE2

X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Phosphoribosylaminoimidazole-succinocarboxamide synthase	polymer	255	29208.1	2	UniProt (Q07296) Pfam (PF01259)	Streptococcus pneumoniae	SAICAR synthetase
2	C, K (A, B)	5-AMINOIMIDAZOLE RIBONUCLEOTIDE	non-polymer		295.2	2	Chemie (AIR)
3	D, L (A, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
4	E, M (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	F, I, J, N (A, B)	TRIS-HYDROXYMETHYL-METHYL-AMMONIUM	non-polymer		122.1	4	Chemie (144)
6	G (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7	H (A)	ASPARTIC ACID	non-polymer		133.1	1	Chemie (ASP)
8	O (B)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
9	P, Q (A, B)	water	water		18.0	414	Chemie (HOH)

Sequence modifications

A, B: 1 - 235 (UniProt: Q07296)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58416.1
Non-Polymers*	Number of molecules	13
	Total formula weight	2209.6
All*	Total formula weight	60625.7

*Water molecules are not included.