4FE2
X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009236 | biological_process | cobalamin biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009236 | biological_process | cobalamin biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE AIR A 301 |
| Chain | Residue |
| A | ARG93 |
| A | ARG214 |
| A | ASP306 |
| A | HOH402 |
| A | HOH412 |
| A | HOH495 |
| A | HOH555 |
| A | GLY98 |
| A | SER99 |
| A | ASP174 |
| A | LYS176 |
| A | ASP196 |
| A | ASN197 |
| A | CYS198 |
| A | ARG199 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP A 302 |
| Chain | Residue |
| A | TYR7 |
| A | GLY9 |
| A | LYS10 |
| A | ALA11 |
| A | LYS12 |
| A | ILE14 |
| A | HIS68 |
| A | LYS81 |
| A | VAL83 |
| A | ILE85 |
| A | LYS122 |
| A | GLU178 |
| A | ASP191 |
| A | MG303 |
| A | ASP306 |
| A | HOH505 |
| A | HOH506 |
| A | HOH517 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 303 |
| Chain | Residue |
| A | ADP302 |
| A | ASP306 |
| A | HOH504 |
| A | HOH505 |
| A | HOH506 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 144 A 304 |
| Chain | Residue |
| A | ASN61 |
| A | VAL62 |
| A | GLY64 |
| A | HOH559 |
| A | HOH601 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 305 |
| Chain | Residue |
| A | ARG103 |
| B | ARG103 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ASP A 306 |
| Chain | Residue |
| A | LYS10 |
| A | GLU89 |
| A | LYS176 |
| A | ASP191 |
| A | ASN197 |
| A | AIR301 |
| A | ADP302 |
| A | MG303 |
| A | HOH504 |
| A | HOH505 |
| A | HOH535 |
| A | HOH555 |
| A | HOH571 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 144 A 307 |
| Chain | Residue |
| A | ALA63 |
| A | GLY64 |
| A | GLU153 |
| A | ARG156 |
| A | HOH579 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 144 A 308 |
| Chain | Residue |
| A | ASN94 |
| A | TYR95 |
| A | ALA111 |
| A | LEU112 |
| A | GLU113 |
| A | HOH523 |
| A | HOH537 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE AIR B 301 |
| Chain | Residue |
| B | GLU89 |
| B | ARG93 |
| B | ALA97 |
| B | SER99 |
| B | ASP174 |
| B | LYS176 |
| B | ASP196 |
| B | ASN197 |
| B | CYS198 |
| B | ARG199 |
| B | ARG214 |
| B | HOH403 |
| B | HOH406 |
| B | HOH487 |
| B | HOH512 |
| site_id | BC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP B 302 |
| Chain | Residue |
| B | HOH475 |
| B | HOH556 |
| B | TYR7 |
| B | GLY9 |
| B | LYS10 |
| B | ALA11 |
| B | LYS12 |
| B | ILE14 |
| B | HIS68 |
| B | LYS81 |
| B | VAL83 |
| B | ILE85 |
| B | GLU178 |
| B | ASP191 |
| B | MG303 |
| B | HOH415 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 303 |
| Chain | Residue |
| B | ADP302 |
| B | HOH415 |
| B | HOH508 |
| B | HOH509 |
| B | HOH556 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 144 B 304 |
| Chain | Residue |
| A | LYS102 |
| A | ARG103 |
| B | LEU126 |
| B | ASP127 |
| B | PRO129 |
| B | HOH532 |
| B | HOH543 |
| B | HOH555 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 305 |
| Chain | Residue |
| B | ASN94 |
| B | TYR95 |
| B | ALA111 |
| B | LEU112 |
| B | HOH542 |
Functional Information from PROSITE/UniProt
