4FDI

The molecular basis of mucopolysaccharidosis IV A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	N-acetylgalactosamine-6-sulfatase	polymer	502	56301.4	2	UniProt (P34059) Pfam (PF00884) Pfam (PF14707)	Homo sapiens (human)	GALNS, Chondroitinsulfatase, Chondroitinase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, GalNAc6S sulfatase
2	C, D, H, I (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
3	E, J (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4	F, K (A, B)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
5	G, L (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	M, N (A, B)	water	water		18.0	775	Chemie (HOH)

Sequence modifications

A, B: 27 - 522 (UniProt: P34059)

PDB	External Database	Details
His 523	-	expression tag
His 524	-	expression tag
His 525	-	expression tag
His 526	-	expression tag
His 527	-	expression tag
His 528	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112602.9
Non-Polymers*	Number of molecules	10
	Total formula weight	1533.4
All*	Total formula weight	114136.3

*Water molecules are not included.