4FDI
The molecular basis of mucopolysaccharidosis IV A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003943 | molecular_function | N-acetylgalactosamine-4-sulfatase activity |
| A | 0004065 | molecular_function | arylsulfatase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0008484 | molecular_function | sulfuric ester hydrolase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030207 | biological_process | chondroitin sulfate proteoglycan catabolic process |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043890 | molecular_function | N-acetylgalactosamine-6-sulfatase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0003943 | molecular_function | N-acetylgalactosamine-4-sulfatase activity |
| B | 0004065 | molecular_function | arylsulfatase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005764 | cellular_component | lysosome |
| B | 0008484 | molecular_function | sulfuric ester hydrolase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030207 | biological_process | chondroitin sulfate proteoglycan catabolic process |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0043890 | molecular_function | N-acetylgalactosamine-6-sulfatase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00149 |
| Number of Residues | 11 |
| Details | SULFATASE_2 Sulfatases signature 2. GYvSkiVGK.WH |
| Chain | Residue | Details |
| A | GLY132-HIS142 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"22940367","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P15289","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22940367","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"via 3-oxoalanine","evidences":[{"source":"PubMed","id":"22940367","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3-oxoalanine (Cys)","evidences":[{"source":"PubMed","id":"22940367","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22940367","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22940367","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
