4FC0
Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 284 | 32322.4 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | A, B | 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide | non-polymer | 579.0 | 2 | Chemie (0T2) | |||
| 3 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, B: 444 - 725 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 442 | - | expression tag |
| Ser 443 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64644.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1158.1 | |
| All* | Total formula weight | 65802.8 |
