Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4FC0

Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 0T2 A 901
ChainResidue
AALA480
ATRP530
ACYS531
AGLY533
AILE591
AGLY592
AASP593
APHE594
AHOH1034
ALYS482
AGLU500
AVAL503
ALEU504
ALEU513
AILE526
ATHR528
AGLN529

site_idAC2
Number of Residues20
DetailsBINDING SITE FOR RESIDUE 0T2 B 901
ChainResidue
BVAL470
BALA480
BLYS482
BGLU500
BVAL503
BLEU504
BLEU513
BILE526
BTHR528
BGLN529
BTRP530
BCYS531
BGLY533
BLEU566
BHIS573
BPHE582
BGLY592
BASP593
BPHE594
BALA597

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues21
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK
ChainResidueDetails
AILE462-LYS482

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL
ChainResidueDetails
AILE571-LEU583

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP575
BASP575

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BILE462
BLYS482
AILE462
ALYS482

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER445
BSER445

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER446
ASER446

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
ChainResidueDetails
BARG670
AARG670

site_idSWS_FT_FI6
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581
ChainResidueDetails
BLYS577
ALYS577

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon