4F9G

Crystal structure of STING complex with Cyclic di-GMP.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	Transmembrane protein 173	polymer	265	29848.5	2	UniProt (Q86WV6) Pfam (PF15009)	Homo sapiens (human)	Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING
2	C (A)	9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)	non-polymer		690.4	1	Chemie (C2E) PubChem (135440063) PubChem (135566344) PubChem (136437725) PubChem (136465801) PubChem (136503951) PubChem (146177770) PubChem (135566464) PubChem (135625254) PubChem (135867623) PubChem (135975628) PubChem (136177399) PubChem (136443483) PubChem (137221491) PubChem (137295286) PubChem (148921766) PubChem (148921769) PubChem (173716374) PubChem (174009991) PubChem (164708340) PubChem (168270823)

Sequence modifications

A, C: 139 - 379 (UniProt: Q86WV6)

PDB	External Database	Details
Met 115	-	initiating methionine
His 116	-	expression tag
His 117	-	expression tag
His 118	-	expression tag
His 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
Ser 122	-	expression tag
Ser 123	-	expression tag
Gly 124	-	expression tag
Val 125	-	expression tag
Asp 126	-	expression tag
Leu 127	-	expression tag
Gly 128	-	expression tag
Thr 129	-	expression tag
Glu 130	-	expression tag
Asn 131	-	expression tag
Leu 132	-	expression tag
Tyr 133	-	expression tag
Phe 134	-	expression tag
Gln 135	-	expression tag
Ser 136	-	expression tag
Asn 137	-	expression tag
Ala 138	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59696.9
Non-Polymers*	Number of molecules	1
	Total formula weight	690.4
All*	Total formula weight	60387.3

*Water molecules are not included.