4F9G

Crystal structure of STING complex with Cyclic di-GMP.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	Transmembrane protein 173	polymer	265	29848.5	2	UniProt (Q86WV6) Pfam (PF15009)	Homo sapiens (human)	Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING
2	C (A)	9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)	non-polymer		690.4	1	Chemie (C2E)

Sequence modifications

A, C: 139 - 379 (UniProt: Q86WV6)

PDB	External Database	Details
Met 115	-	initiating methionine
His 116	-	expression tag
His 117	-	expression tag
His 118	-	expression tag
His 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
Ser 122	-	expression tag
Ser 123	-	expression tag
Gly 124	-	expression tag
Val 125	-	expression tag
Asp 126	-	expression tag
Leu 127	-	expression tag
Gly 128	-	expression tag
Thr 129	-	expression tag
Glu 130	-	expression tag
Asn 131	-	expression tag
Leu 132	-	expression tag
Tyr 133	-	expression tag
Phe 134	-	expression tag
Gln 135	-	expression tag
Ser 136	-	expression tag
Asn 137	-	expression tag
Ala 138	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59696.9
Non-Polymers*	Number of molecules	1
	Total formula weight	690.4
All*	Total formula weight	60387.3

*Water molecules are not included.