4F9G
Crystal structure of STING complex with Cyclic di-GMP.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Transmembrane protein 173 | polymer | 265 | 29848.5 | 2 | UniProt (Q86WV6) Pfam (PF15009) In PDB | Homo sapiens (human) | Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING |
2 | A | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) | non-polymer | 690.4 | 1 | Chemie (C2E) |
Sequence modifications
A, C: 139 - 379 (UniProt: Q86WV6)
PDB | External Database | Details |
---|---|---|
Met 115 | - | initiating methionine |
His 116 | - | expression tag |
His 117 | - | expression tag |
His 118 | - | expression tag |
His 119 | - | expression tag |
His 120 | - | expression tag |
His 121 | - | expression tag |
Ser 122 | - | expression tag |
Ser 123 | - | expression tag |
Gly 124 | - | expression tag |
Val 125 | - | expression tag |
Asp 126 | - | expression tag |
Leu 127 | - | expression tag |
Gly 128 | - | expression tag |
Thr 129 | - | expression tag |
Glu 130 | - | expression tag |
Asn 131 | - | expression tag |
Leu 132 | - | expression tag |
Tyr 133 | - | expression tag |
Phe 134 | - | expression tag |
Gln 135 | - | expression tag |
Ser 136 | - | expression tag |
Asn 137 | - | expression tag |
Ala 138 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 59696.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 690.4 | |
All* | Total formula weight | 60387.3 |