4F5Y
Crystal structure of human STING CTD complex with C-di-GMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transmembrane protein 173 | polymer | 239 | 27239.6 | 2 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING |
| 2 | C, E (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 3 | D (A) | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) | non-polymer | 690.4 | 1 | Chemie (C2E) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A, B: 149 - 379 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Arg 232 | His 232 | SEE REMARK 999 |
| Leu 380 | - | expression tag |
| Glu 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54479.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 770.6 | |
| All* | Total formula weight | 55249.8 |
