4F5Y

Crystal structure of human STING CTD complex with C-di-GMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transmembrane protein 173	polymer	239	27239.6	2	UniProt (Q86WV6) Pfam (PF15009) In PDB	Homo sapiens (human)	Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING
2	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
3	A	9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)	non-polymer		690.4	1	Chemie (C2E)
4		water	water		18.0	138	Chemie (HOH)

Sequence modifications

A, B: 149 - 379 (UniProt: Q86WV6)

PDB	External Database	Details
Arg 232	His 232	SEE REMARK 999
Leu 380	-	expression tag
Glu 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54479.2
Non-Polymers*	Number of molecules	3
	Total formula weight	770.6
All*	Total formula weight	55249.8

*Water molecules are not included.