4F5Y
Crystal structure of human STING CTD complex with C-di-GMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transmembrane protein 173 | polymer | 239 | 27239.6 | 2 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING |
| 2 | C, E (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 3 | D (A) | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) | non-polymer | 690.4 | 1 | Chemie (C2E) PubChem (135440063) PubChem (135566344) PubChem (136437725) PubChem (136465801) PubChem (136503951) PubChem (146177770) PubChem (173716374) PubChem (174009991) PubChem (135566464) PubChem (135625254) PubChem (135867623) PubChem (135975628) PubChem (136177399) PubChem (136443483) PubChem (137221491) PubChem (137295286) PubChem (148921766) PubChem (148921769) PubChem (164708340) PubChem (168270823) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A, B: 149 - 379 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Arg 232 | His 232 | SEE REMARK 999 |
| Leu 380 | - | expression tag |
| Glu 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54479.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 770.6 | |
| All* | Total formula weight | 55249.8 |
