4F5E

Crystal structure of ERIS/STING

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Transmembrane protein 173	polymer	256	28623.4	1	UniProt (Q86WV6) Pfam (PF15009) In PDB	Homo sapiens (human)	Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING
2	A	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
3		water	water		18.0	31	Chemie (HOH)

Sequence modifications

A: 141 - 379 (UniProt: Q86WV6)

PDB	External Database	Details
Gly 124	-	expression tag
Ser 125	-	expression tag
His 126	-	expression tag
Met 127	-	expression tag
Ala 128	-	expression tag
Ser 129	-	expression tag
Met 130	-	expression tag
Thr 131	-	expression tag
Gly 132	-	expression tag
Gly 133	-	expression tag
Met 134	-	expression tag
Gly 135	-	expression tag
Arg 136	-	expression tag
Gly 137	-	expression tag
Ser 138	-	expression tag
Met 139	-	expression tag
Met 140	-	expression tag
Ala 230	Gly 230	engineered mutation
Arg 232	His 232	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28623.4
Non-Polymers*	Number of molecules	1
	Total formula weight	238.3
All*	Total formula weight	28861.7

*Water molecules are not included.