4EWS
Crystal structure of cholesteryl ester transfer protein in complex with inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CETP | polymer | 476 | 53097.8 | 1 | UniProt (P11597) Pfam (PF01273) Pfam (PF02886) | Homo sapiens | |
| 2 | B (B) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G47477HI) | |||
| 3 | C, D (A) | CHOLESTERYL OLEATE | non-polymer | 651.1 | 2 | Chemie (2OB) PubChem (20839141) PubChem (24826492) PubChem (25009314) PubChem (45109798) PubChem (44602420) PubChem (50938266) PubChem (53393578) PubChem (54269527) PubChem (56845626) PubChem (54269525) PubChem (57237989) PubChem (5283632) PubChem (68036128) PubChem (5379501) PubChem (6383527) PubChem (6537189) PubChem (78971) PubChem (644119) PubChem (15565228) PubChem (99564897) PubChem (99565618) PubChem (99565619) PubChem (99564896) PubChem (99564898) PubChem (124896896) PubChem (124896894) PubChem (124904678) PubChem (9986749) PubChem (124896395) PubChem (124896895) PubChem (124904677) PubChem (124904679) PubChem (124907353) PubChem (124907354) PubChem (124907355) PubChem (15565226) PubChem (146019047) PubChem (154825233) PubChem (175077375) PubChem (176430250) PubChem (163067668) PubChem (172399964) | |||
| 4 | E (A) | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 782.1 | 1 | Chemie (DLP) PubChem (3034686) PubChem (160855) PubChem (24778969) PubChem (24778975) PubChem (46936959) PubChem (5288075) PubChem (6440944) PubChem (6168933) PubChem (6509852) | |||
| 5 | F, G (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 6 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 7 | I (A) | ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H )-carboxylate | non-polymer | 600.5 | 1 | Chemie (0RP) PubChem (59827132) PubChem (86584714) PubChem (159325) PubChem (9851652) PubChem (10210810) PubChem (88104629) PubChem (88556232) PubChem (124557520) | |||
| 8 | J (A) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A: 1 - 476 (UniProt: P11597)
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | Cys 18 | engineered mutation |
| Asp 88 | Asn 105 | engineered mutation |
| Ala 131 | Cys 148 | engineered mutation |
| Asp 240 | Asn 257 | engineered mutation |
| Asp 341 | Asn 358 | engineered mutation |
| Ile 405 | Val 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53097.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 732.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3020.6 | |
| All* | Total formula weight | 56851.0 |
