4EWS
Crystal structure of cholesteryl ester transfer protein in complex with inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CETP | polymer | 476 | 53097.8 | 1 | UniProt (P11597) Pfam (PF01273) Pfam (PF02886) | Homo sapiens | |
| 2 | B (B) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G47477HI) | |||
| 3 | C, D (A) | CHOLESTERYL OLEATE | non-polymer | 651.1 | 2 | Chemie (2OB) | |||
| 4 | E (A) | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 782.1 | 1 | Chemie (DLP) | |||
| 5 | F, G (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 6 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | I (A) | ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H )-carboxylate | non-polymer | 600.5 | 1 | Chemie (0RP) | |||
| 8 | J (A) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A: 1 - 476 (UniProt: P11597)
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | Cys 18 | engineered mutation |
| Asp 88 | Asn 105 | engineered mutation |
| Ala 131 | Cys 148 | engineered mutation |
| Asp 240 | Asn 257 | engineered mutation |
| Asp 341 | Asn 358 | engineered mutation |
| Ile 405 | Val 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53097.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 732.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3020.6 | |
| All* | Total formula weight | 56851.0 |
