4EW0
mouse MBD4 glycosylase domain in complex with a G:5hmU (5-hydroxymethyluracil) mismatch
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Methyl-CpG-binding domain protein 4 | polymer | 146 | 17563.2 | 1 | UniProt (Q9Z2D7) In PDB | Mus musculus (mouse) | Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase |
| 2 | B | DNA (5'-D(*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3') | polymer | 11 | 3374.2 | 1 | |||
| 3 | C | DNA (5'-D(*CP*CP*AP*TP*GP*(5HU)P*GP*CP*TP*GP*A)-3') | polymer | 11 | 3365.2 | 1 | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | A | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 6 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 411 - 554 (UniProt: Q9Z2D7)
| PDB | External Database | Details |
|---|---|---|
| His 409 | - | expression tag |
| Met 410 | - | expression tag |
| Asn 534 | Asp 534 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 24302.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 244.9 | |
| All* | Total formula weight | 24547.5 |
