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4ER5

Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Histone-lysine N-methyltransferase, H3 lysine-79 specificpolymer41347050.51UniProt (Q8TEK3)
Pfam (PF08123)
Homo sapiens (human)DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4
2B, C
(A)
7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-aminenon-polymer539.72Chemie (0QK)
3D, E, F, G, H
(A)
UNKNOWN ATOM OR IONnon-polymer5Chemie (UNX)
4I
(A)
waterwater18.020Chemie (HOH)
Sequence modifications
A: 1 - 412 (UniProt: Q8TEK3)
PDBExternal DatabaseDetails
Gly 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight47050.5
Non-Polymers*Number of molecules7
Total formula weight1079.3
All*Total formula weight48129.9
*Water molecules are not included.

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PDB entries from 2025-07-30

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