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4ER5

Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 0QK A 501
ChainResidue
ATYR128
AGLY221
AASP222
APHE223
AASN241
APHE245
ASER268
ASER269
ALEU143
AASP161
AGLY163
ASER164
AGLY165
AVAL169
AGLU186
ALYS187

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0QK A 502
ChainResidue
AGLU46
ALEU111
ATYR115
APRO122
AGLU123
ALEU125
AASN126
AASN127
ATYR128
APRO133
ATYR136
AGLY137
AGLN168

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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