4ER5
Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 0QK A 501 |
Chain | Residue |
A | TYR128 |
A | GLY221 |
A | ASP222 |
A | PHE223 |
A | ASN241 |
A | PHE245 |
A | SER268 |
A | SER269 |
A | LEU143 |
A | ASP161 |
A | GLY163 |
A | SER164 |
A | GLY165 |
A | VAL169 |
A | GLU186 |
A | LYS187 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 0QK A 502 |
Chain | Residue |
A | GLU46 |
A | LEU111 |
A | TYR115 |
A | PRO122 |
A | GLU123 |
A | LEU125 |
A | ASN126 |
A | ASN127 |
A | TYR128 |
A | PRO133 |
A | TYR136 |
A | GLY137 |
A | GLN168 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | TYR136 | |
A | PHE159 | |
A | GLU186 | |
A | ASP222 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER297 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER374 |