4ER3
Crystal Structure of Human DOT1L in complex with inhibitor EPZ004777
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 352 | 40808.3 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (human) | DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 |
| 2 | B (A) | 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine | non-polymer | 539.7 | 1 | Chemie (0QK) | |||
| 3 | C, D, E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | H, I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | J, K, L, M, N... (A) | UNKNOWN ATOM OR ION | non-polymer | 6 | Chemie (UNX) | ||||
| 6 | P (A) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 1 - 351 (UniProt: Q8TEK3)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40808.3 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1144.1 | |
| All* | Total formula weight | 41952.4 |
