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4ER3

Crystal Structure of Human DOT1L in complex with inhibitor EPZ004777

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 0QK A 401
ChainResidue
AMET147
APHE223
AASN241
APHE245
ASER268
ATYR312
AASP161
AGLY163
ASER164
AVAL169
AGLU186
ALYS187
AGLY221
AASP222

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 402
ChainResidue
AASN99
AARG101

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SO4 A 403
ChainResidue
ATHR104

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 404
ChainResidue
ASER67
APHE68
AGLU69

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 405
ChainResidue
AHIS117
AGLU201
ALYS204
ALYS300

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 406
ChainResidue
AARG203
ALYS207
AHIS213

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 407
ChainResidue
AVAL160
ATYR183
ATHR235

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 408
ChainResidue
AARG229
AARG256

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ATYR136
APHE159
AGLU186
AASP222

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER297

227111

PDB entries from 2024-11-06

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