4EQZ
Crystal structure of human DOT1L in complex with inhibitor FED2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 421 | 47980.7 | 1 | UniProt (Q8TEK3) Pfam (PF08123) In PDB | Homo sapiens (human) | DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 |
| 2 | A | 5'-deoxy-5'-[(3-{[(4-methylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]adenosine | non-polymer | 498.6 | 1 | Chemie (AW0) | |||
| 3 | A | UNKNOWN ATOM OR ION | non-polymer | 6 | Chemie (UNX) | ||||
| 4 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 1 - 420 (UniProt: Q8TEK3)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47980.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 498.6 | |
| All* | Total formula weight | 48479.3 |
