4EP3
Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | protease, tethered dimer | polymer | 203 | 22005.0 | 1 | UniProt (P03369) Pfam (PF00077) In PDB | HIV-1 M:B_ARV2/SF2 (HIV-1) | |
2 | E | substrate CA-p2 | polymer | 9 | 990.2 | 1 | UniProt (Q9YP46) In PDB | Human immunodeficiency virus 1 | |
3 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
4 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
5 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: P03369)
A: 101 - 199 (UniProt: P03369)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 497 | engineered mutation |
Asn 25 | Asp 515 | engineered mutation |
Leu 67 | Cys 557 | engineered mutation |
Met 95 | Cys 585 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 99 | - | linker |
Gly 99 | - | linker |
Ser 99 | - | linker |
Ser 99 | - | linker |
Gly 99 | - | linker |
Lys 107 | Gln 497 | engineered mutation |
Asn 125 | Asp 515 | engineered mutation |
Leu 167 | Cys 557 | engineered mutation |
Met 195 | Cys 585 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 22995.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 354.4 | |
All* | Total formula weight | 23349.6 |