4EP3

Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 201

Chain	Residue
A	ARG14
A	GLY17
A	PRO63
A	GLU65
A	GLY117
A	HOH340

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 202

Chain	Residue
A	PRO139
A	GLY140
A	LYS20
A	MET36
A	ASN37

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 203

Chain	Residue
A	TRP6
A	ASP129
A	ARG187
A	ASN188

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 204

Chain	Residue
A	ARG87
A	LYS107
A	ARG108

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site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR CHAIN E OF SUBSTRATE CA-P2

Chain	Residue
A	ARG8
A	ASN25
A	GLY27
A	ALA28
A	ASP29
A	ASP30
A	MET46
A	ILE47
A	GLY48
A	GLY49
A	ILE50
A	LEU76
A	VAL82
A	ILE84
A	ARG108
A	ASN125
A	GLY127
A	ALA128
A	ASP129
A	ASP130
A	GLY148
A	GLY149
A	ILE150
A	ILE184
A	HOH323
E	HOH101
E	HOH102

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	69
Details	Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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