4EOK
Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cyclin-dependent kinase 2 | polymer | 300 | 34138.5 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2, p33 protein kinase |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (human) | Cyclin-A |
| 3 | E, G (A, C) | O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE | non-polymer | 402.5 | 2 | Chemie (4SP) | |||
| 4 | F, H (B, D) | MONOTHIOGLYCEROL | non-polymer | 108.2 | 2 | Chemie (SGM) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 297 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ser 84 | His 84 | engineered mutation |
| Met 85 | Gln 85 | engineered mutation |
| Asp 89 | Lys 89 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127525.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1021.3 | |
| All* | Total formula weight | 128546.9 |
