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4EOK

Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000086biological_processG2/M transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000781cellular_componentchromosome, telomeric region
A0000793cellular_componentcondensed chromosome
A0000805cellular_componentX chromosome
A0000806cellular_componentY chromosome
A0001673cellular_componentmale germ cell nucleus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006338biological_processchromatin remodeling
A0006351biological_processDNA-templated transcription
A0006468biological_processprotein phosphorylation
A0006813biological_processpotassium ion transport
A0006974biological_processDNA damage response
A0007049biological_processcell cycle
A0007099biological_processcentriole replication
A0007165biological_processsignal transduction
A0007265biological_processRas protein signal transduction
A0007346biological_processregulation of mitotic cell cycle
A0008284biological_processpositive regulation of cell population proliferation
A0010033biological_processresponse to organic substance
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010468biological_processregulation of gene expression
A0015030cellular_componentCajal body
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019904molecular_functionprotein domain specific binding
A0030332molecular_functioncyclin binding
A0031453biological_processpositive regulation of heterochromatin formation
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0032298biological_processpositive regulation of DNA-templated DNA replication initiation
A0035173molecular_functionhistone kinase activity
A0043687biological_processpost-translational protein modification
A0045740biological_processpositive regulation of DNA replication
A0045893biological_processpositive regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0051298biological_processcentrosome duplication
A0051301biological_processcell division
A0051321biological_processmeiotic cell cycle
A0071732biological_processcellular response to nitric oxide
A0090398biological_processcellular senescence
A0097123cellular_componentcyclin A1-CDK2 complex
A0097124cellular_componentcyclin A2-CDK2 complex
A0097134cellular_componentcyclin E1-CDK2 complex
A0097135cellular_componentcyclin E2-CDK2 complex
A0097472molecular_functioncyclin-dependent protein kinase activity
A0106310molecular_functionprotein serine kinase activity
A1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0044772biological_processmitotic cell cycle phase transition
C0000082biological_processG1/S transition of mitotic cell cycle
C0000086biological_processG2/M transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0000781cellular_componentchromosome, telomeric region
C0000793cellular_componentcondensed chromosome
C0000805cellular_componentX chromosome
C0000806cellular_componentY chromosome
C0001673cellular_componentmale germ cell nucleus
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005654cellular_componentnucleoplasm
C0005667cellular_componenttranscription regulator complex
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006260biological_processDNA replication
C0006281biological_processDNA repair
C0006338biological_processchromatin remodeling
C0006351biological_processDNA-templated transcription
C0006468biological_processprotein phosphorylation
C0006813biological_processpotassium ion transport
C0006974biological_processDNA damage response
C0007049biological_processcell cycle
C0007099biological_processcentriole replication
C0007165biological_processsignal transduction
C0007265biological_processRas protein signal transduction
C0007346biological_processregulation of mitotic cell cycle
C0008284biological_processpositive regulation of cell population proliferation
C0010033biological_processresponse to organic substance
C0010389biological_processregulation of G2/M transition of mitotic cell cycle
C0010468biological_processregulation of gene expression
C0015030cellular_componentCajal body
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0016740molecular_functiontransferase activity
C0018105biological_processpeptidyl-serine phosphorylation
C0019904molecular_functionprotein domain specific binding
C0030332molecular_functioncyclin binding
C0031453biological_processpositive regulation of heterochromatin formation
C0031571biological_processmitotic G1 DNA damage checkpoint signaling
C0032298biological_processpositive regulation of DNA-templated DNA replication initiation
C0035173molecular_functionhistone kinase activity
C0043687biological_processpost-translational protein modification
C0045740biological_processpositive regulation of DNA replication
C0045893biological_processpositive regulation of DNA-templated transcription
C0046872molecular_functionmetal ion binding
C0051298biological_processcentrosome duplication
C0051301biological_processcell division
C0051321biological_processmeiotic cell cycle
C0071732biological_processcellular response to nitric oxide
C0090398biological_processcellular senescence
C0097123cellular_componentcyclin A1-CDK2 complex
C0097124cellular_componentcyclin A2-CDK2 complex
C0097134cellular_componentcyclin E1-CDK2 complex
C0097135cellular_componentcyclin E2-CDK2 complex
C0097472molecular_functioncyclin-dependent protein kinase activity
C0106310molecular_functionprotein serine kinase activity
C1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
D0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
D0044772biological_processmitotic cell cycle phase transition
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 4SP A 301
ChainResidue
AGLU12
AASP89
AASN132
ALEU134
AASP145
AALA31
AVAL64
APHE80
AGLU81
ALEU83
ASER84
AMET85
AASP86

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SGM B 501
ChainResidue
BMET189
BCYS193

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 4SP C 301
ChainResidue
CILE10
CALA31
CVAL64
CPHE80
CGLU81
CPHE82
CLEU83
CSER84
CMET85
CASP86
CASP89
CGLN131
CASN132
CLEU134
CASP145

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SGM D 501
ChainResidue
DLYS192
DCYS193
DARG241
DASP305

Functional Information from PROSITE/UniProt
site_idPS00292
Number of Residues32
DetailsCYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
ChainResidueDetails
BARG211-PHE242

site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
ChainResidueDetails
AILE10-LYS33

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
AVAL123-ILE135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP127
CASP127

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
ChainResidueDetails
AILE10
CLYS129
ALYS33
AGLU81
AASP86
ALYS129
CILE10
CLYS33
CGLU81
CASP86

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:21565702
ChainResidueDetails
AASN132
AASP145
CASN132
CASP145

site_idSWS_FT_FI4
Number of Residues6
DetailsSITE: CDK7 binding
ChainResidueDetails
ALYS9
ALYS88
ALEU166
CLYS9
CLYS88
CLEU166

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1
CMET1

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS6
CLYS6

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
ChainResidueDetails
ATHR14
CTHR14

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR15
CTYR15

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR19
CTYR19

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
ChainResidueDetails
ATPO160
CTPO160

217705

PDB entries from 2024-03-27

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