4ELL

Structure of the inactive retinoblastoma protein pocket domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Retinoblastoma-associated protein	polymer	411	47675.0	2	UniProt (P06400) Pfam (PF01858) Pfam (PF01857)	Homo sapiens (human)	p105-Rb, pRb, Rb, pp110
2	C, D (A, B)	water	water		18.0	355	Chemie (HOH)

Sequence modifications

A, B: 380 - 787 (UniProt: P06400)

PDB	External Database	Details
Gly 377	-	expression tag
Glu 378	-	expression tag
Phe 379	-	expression tag
Phe 561	Leu 561	engineered mutation
Glu 608	Ser 608	engineered mutation
Ala 612	Ser 612	conflict
Ala 780	Ser 780	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95350.0
All*	Total formula weight	95350.0

*Water molecules are not included.