4EKK
Akt1 with AMP-PNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RAC-alpha serine/threonine-protein kinase | polymer | 341 | 39467.0 | 2 | UniProt (P31749) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha |
| 2 | C, D (C, D) | Glycogen synthase kinase-3 beta | polymer | 10 | 1123.2 | 2 | UniProt (P49841) | Homo sapiens | GSK-3 beta, Serine/threonine-protein kinase GSK3B |
| 3 | E, H (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | F, G, I, J (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 5 | K, L, M (A, B, D) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B: 144 - 480 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Gly 140 | - | expression tag |
| Ala 141 | - | expression tag |
| Met 142 | - | expression tag |
| Ala 143 | - | expression tag |
| Asp 473 | Ser 473 | engineered mutation |
| Ser 478 | Gly 478 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81180.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1232.1 | |
| All* | Total formula weight | 82412.5 |
