4EHZ
The Jak1 kinase domain in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 4 | UniProt (P23458) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 1, JAK-1 |
| 2 | E, K, M, R (A, B, C, D) | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | non-polymer | 255.3 | 4 | Chemie (JAK) | |||
| 3 | F, G, H, I, J... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 4 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 561 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138986.4 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1766.1 | |
| All* | Total formula weight | 140752.5 |
