4EC8

Structure of full length CDK9 in complex with cyclinT and DRB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 9	polymer	373	42940.4	1	UniProt (P50750) Pfam (PF00069) In PDB	Homo sapiens (human)	C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit
2	B	Cyclin-T1	polymer	260	30119.4	1	UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB	Homo sapiens (human)	CycT1, Cyclin-T

Sequence modifications

A: 2 - 372 (UniProt: P50750)

PDB	External Database	Details
Gly 0	-	EXPRESSION TAG
Pro 1	-	EXPRESSION TAG

B: 2 - 259 (UniProt: O60563)

PDB	External Database	Details
Gly 0	-	EXPRESSION TAG
Pro 1	-	EXPRESSION TAG
Arg 77	Gln 77	ENGINEERED MUTATION
Gly 96	Glu 96	ENGINEERED MUTATION
Leu 241	Phe 241	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73059.9
All*	Total formula weight	73059.9

*Water molecules are not included.