4EAQ

Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with 3'-Azido-3'-Deoxythymidine-5'-Monophosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Thymidylate kinase	polymer	229	26198.5	2	UniProt (P65248) Pfam (PF02223)	Staphylococcus aureus subsp. aureus	dTMP kinase
2	C, D (A, B)	3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE	non-polymer		347.2	2	Chemie (ATM)
3	E, F (A, B)	water	water		18.0	143	Chemie (HOH)

Sequence modifications

A, B: 1 - 205 (UniProt: P65248)

PDB	External Database	Details
Met -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Leu -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52397.0
Non-Polymers*	Number of molecules	2
	Total formula weight	694.4
All*	Total formula weight	53091.5

*Water molecules are not included.