4EAQ
Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with 3'-Azido-3'-Deoxythymidine-5'-Monophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004798 | molecular_function | dTMP kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0004798 | molecular_function | dTMP kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ATM A 301 |
| Chain | Residue |
| A | PHE-4 |
| A | TYR100 |
| A | GLN101 |
| A | HOH481 |
| A | GLU11 |
| A | LYS15 |
| A | ARG36 |
| A | GLU37 |
| A | PHE66 |
| A | ARG70 |
| A | ARG92 |
| A | SER97 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ATM B 301 |
| Chain | Residue |
| B | GLU11 |
| B | LYS15 |
| B | ARG36 |
| B | GLU37 |
| B | ARG48 |
| B | PHE66 |
| B | ARG70 |
| B | ARG92 |
| B | SER97 |
| B | TYR100 |
| B | GLN101 |
| B | HOH427 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. LCDRYidSSlAYQ |
| Chain | Residue | Details |
| A | LEU89-GLN101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00165","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
