4EAQ

Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with 3'-Azido-3'-Deoxythymidine-5'-Monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004798	molecular_function	thymidylate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016597	molecular_function	amino acid binding
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0004798	molecular_function	thymidylate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006227	biological_process	dUDP biosynthetic process
B	0006233	biological_process	dTDP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016597	molecular_function	amino acid binding
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ATM A 301

Chain	Residue
A	PHE-4
A	TYR100
A	GLN101
A	HOH481
A	GLU11
A	LYS15
A	ARG36
A	GLU37
A	PHE66
A	ARG70
A	ARG92
A	SER97

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ATM B 301

Chain	Residue
B	GLU11
B	LYS15
B	ARG36
B	GLU37
B	ARG48
B	PHE66
B	ARG70
B	ARG92
B	SER97
B	TYR100
B	GLN101
B	HOH427

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Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. LCDRYidSSlAYQ

Chain	Residue	Details
A	LEU89-GLN101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165

Chain	Residue	Details
A	GLY9
B	GLY9

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