4EA5
Structure of the glycoslyase domain of MBD4 bound to a 5hmU containing DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Methyl-CpG-binding domain protein 4 | polymer | 160 | 19234.2 | 1 | UniProt (O95243) In PDB | Homo sapiens (human) | Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase |
| 2 | C | DNA (5'-D(*CP*CP*AP*GP*CP*GP*(5HU)*GP*CP*AP*GP*C)-3') | polymer | 12 | 3664.4 | 1 | |||
| 3 | D | DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3') | polymer | 12 | 3695.4 | 1 | |||
| 4 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 427 - 580 (UniProt: O95243)
| PDB | External Database | Details |
|---|---|---|
| Met 426 | - | expression tag |
| Ala 560 | Asp 560 | conflict |
| His 581 | - | expression tag |
| His 582 | - | expression tag |
| His 583 | - | expression tag |
| His 584 | - | expression tag |
| His 585 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 26594.0 | |
| All* | Total formula weight | 26594.0 |
