4E9G

structure of the glycosylase domain of MBD4 bound to thymine containing DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Methyl-CpG-binding domain protein 4	polymer	161	19372.4	1	UniProt (O95243) In PDB	Homo sapiens (human)	Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase
2	C	DNA (5'-D(*CP*CP*AP*GP*CP*GP*TP*GP*CP*AP*GP*C)-3')	polymer	12	3648.4	1
3	D	DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3')	polymer	12	3695.4	1
4		water	water		18.0	32	Chemie (HOH)

Sequence modifications

A: 427 - 580 (UniProt: O95243)

PDB	External Database	Details
Met 426	-	expression tag
Ala 560	Asp 560	engineered mutation
His 581	-	expression tag
His 582	-	expression tag
His 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	26716.2
All*	Total formula weight	26716.2

*Water molecules are not included.