4E5F

Crystal structure of avian influenza virus PAn bound to compound 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Polymerase protein PA	polymer	187	21916.0	4	UniProt (Q5EP34) In PDB	Influenza A virus	polymerase acidic protein
2	A, B, C, D	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
3	A, B, C, D	MANGANESE (II) ION	non-polymer		54.9	8	Chemie (MN)
4	A, B, C, D	2-hydroxyisoquinoline-1,3(2H,4H)-dione	non-polymer		177.2	4	Chemie (0N7)
5		water	water		18.0	66	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 50 (UniProt: Q5EP34)
A, B, C, D: 73 - 196 (UniProt: Q5EP34)

PDB	External Database	Details
Gly 50	-	linker
Gly 50	-	linker
Ser 50	-	linker
Ala 196	-	expression tag
Ala 196	-	expression tag
Ala 196	-	expression tag
Glu 197	-	expression tag
Leu 198	-	expression tag
Ala 199	-	expression tag
Leu 200	-	expression tag
Val 201	-	expression tag
Pro 202	-	expression tag
Arg 203	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	87663.8
Non-Polymers*	Number of molecules	20
	Total formula weight	1916.6
All*	Total formula weight	89580.5

*Water molecules are not included.