4E5F

Crystal structure of avian influenza virus PAn bound to compound 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0039694	biological_process	viral RNA genome replication
D	0003723	molecular_function	RNA binding
D	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	SER50
A	ARG75
A	LYS113

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	ILE30
A	GLU31
A	THR32
A	ASN33
A	LYS34
A	SER194

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 303

Chain	Residue
A	HIS41
A	ASP108
A	GLU119
A	ILE120
A	0N7305

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 304

Chain	Residue
A	GLU80
A	LEU106
A	PRO107
A	ASP108
A	0N7305

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 0N7 A 305

Chain	Residue
A	HIS41
A	GLU80
A	ASP108
A	GLU119
A	ILE120
A	TYR130
A	LYS134
A	MN303
A	MN304
A	HOH414

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
B	GLY50
B	SER50
B	ARG75
B	LYS113

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	GLU31
B	THR32
B	ASN33
B	LYS34
B	SER194

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 303

Chain	Residue
B	HIS41
B	ASP108
B	GLU119
B	ILE120
B	LYS134
B	0N7305

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN B 304

Chain	Residue
B	GLU80
B	ASP108
B	0N7305

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 0N7 B 305

Chain	Residue
B	HIS41
B	GLU80
B	ASP108
B	GLU119
B	ILE120
B	LYS134
B	MN303
B	MN304
B	HOH401

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 301

Chain	Residue
C	SER50
C	ARG75
C	LYS113

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	GLU31
C	THR32
C	ASN33
C	LYS34
C	SER194

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 303

Chain	Residue
C	HIS41
C	ASP108
C	GLU119
C	ILE120
C	0N7305

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN C 304

Chain	Residue
C	GLU80
C	ASP108
C	0N7305

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 0N7 C 305

Chain	Residue
C	HIS41
C	GLU80
C	ASP108
C	GLU119
C	ILE120
C	TYR130
C	LYS134
C	MN303
C	MN304

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 301

Chain	Residue
D	SER50
D	ARG75
D	LYS113

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 302

Chain	Residue
D	GLU31
D	THR32
D	ASN33
D	LYS34
D	SER194

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 303

Chain	Residue
D	HIS41
D	ASP108
D	GLU119
D	ILE120
D	0N7305

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN D 304

Chain	Residue
D	GLU80
D	PRO107
D	ASP108
D	0N7305

---

site_id	CC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0N7 D 305

Chain	Residue
D	GLU80
D	ASP108
D	GLU119
D	ILE120
D	TYR130
D	LYS134
D	MN303
D	MN304
D	HOH401
D	HOH418
D	HIS41

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Motif: {"description":"Nuclear localization signal 1 (NLS1)","evidences":[{"source":"UniProtKB","id":"P03433","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"22876176","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"4E5E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22876176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E5F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22876176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E5E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22876176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E5G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---