4DZ5
W227F active site mutant of AKR1C3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aldo-keto reductase family 1 member C3 | polymer | 331 | 37938.3 | 1 | UniProt (P42330) Pfam (PF00248) In PDB | Homo sapiens (human) | 17-beta-hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 3-alpha-HSD type II, brain, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-HSD type 2, Chlordecone reductase homolog HAKRb, Dihydrodiol dehydrogenase 3, DD-3, DD3, Dihydrodiol dehydrogenase type I, HA1753, Indanol dehydrogenase, Prostaglandin F synthase, PGFS, Testosterone 17-beta-dehydrogenase 5, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
4 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
6 | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 1 - 323 (UniProt: P42330)
PDB | External Database | Details |
---|---|---|
Phe 227 | Trp 227 | engineered mutation |
Leu 324 | - | expression tag |
Glu 325 | - | expression tag |
His 326 | - | expression tag |
His 327 | - | expression tag |
His 328 | - | expression tag |
His 329 | - | expression tag |
His 330 | - | expression tag |
His 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37938.3 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1120.8 | |
All* | Total formula weight | 39059.1 |