4DVA
The crystal structure of human urokinase-type plasminogen activator catalytic domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | Urokinase-type plasminogen activator | polymer | 246 | 27715.6 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | U-plasminogen activator, uPA |
| 2 | B, C (U) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D, E (U) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 2 | Chemie (P6G) | |||
| 4 | F (U) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
U: 16 - 243 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27715.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 756.8 | |
| All* | Total formula weight | 28472.4 |
