4DVA

The crystal structure of human urokinase-type plasminogen activator catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0004252	molecular_function	serine-type endopeptidase activity
U	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 U 301

Chain	Residue
U	HIS57
U	GLN192
U	GLY193
U	SER195
U	HOH543
U	HOH545
U	HOH547
U	HOH559

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 U 302

Chain	Residue
U	GLN170
U	PRO170
U	HIS170
U	HOH470
U	HOH477
U	ASN87

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P6G U 303

Chain	Residue
U	LEU162
U	ILE163
U	ALA184
U	ASP185
U	PRO185
U	TRP186

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE P6G U 304

Chain	Residue
U	ASN74
U	SER202

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
U	ILE53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
U	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	245
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9151681","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000026"}

Chain

Residue

Details

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