4DTG
Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, light chain | polymer | 219 | 23846.6 | 1 | Homo sapiens (human) | ||
| 2 | B (H) | Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, heavy chain | polymer | 222 | 23745.4 | 1 | Homo sapiens (human) | ||
| 3 | C (K) | Tissue factor pathway inhibitor | polymer | 66 | 7939.8 | 1 | UniProt (P10646) Pfam (PF00014) | Homo sapiens (human) | TFPI, Extrinsic pathway inhibitor, EPI, Lipoprotein-associated coagulation inhibitor, LACI |
| 4 | D, E, F, G, H... (L, H) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 5 | K (H) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 6 | L, M, N (H) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 7 | R, S, T (L, H, K) | water | water | 18.0 | 400 | Chemie (HOH) |
Sequence modifications
K: 1 - 60 (UniProt: P10646)
| PDB | External Database | Details |
|---|---|---|
| His 61 | - | expression tag |
| His 62 | - | expression tag |
| His 63 | - | expression tag |
| His 64 | - | expression tag |
| His 65 | - | expression tag |
| His 66 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 55531.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1566.7 | |
| All* | Total formula weight | 57098.5 |
