4DTG

Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL L 301

Chain	Residue
H	PHE174
L	THR183
L	HOH478
H	PRO175
H	SER185
H	LEU186
H	SER187
L	GLN165
L	SER167
L	SER181
L	SER182

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL L 302

Chain	Residue
L	LYS44
L	GLN50
L	LEU52
L	PRO64
L	PHE67
L	GLU86
L	ASP87

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL L 303

Chain	Residue
L	LEU9
L	TYR92
L	GLY105
L	GLY106

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL L 304

Chain	Residue
L	THR7
L	SER22
L	LYS24
L	SER68
L	HOH508

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL L 305

Chain	Residue
L	PRO15
L	ARG113
L	THR114

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL L 306

Chain	Residue
L	LYS150
L	HIS203
L	GLN204

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL L 307

Chain	Residue
H	ARG218
L	LEU186
L	SER187
L	HOH526
L	HOH570

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MES H 301

Chain	Residue
H	ASN163
H	SER164
H	THR203
H	ASN205
H	ASP216
H	HOH432
L	VAL155
L	GLN160
L	LEU186
L	ASP190
L	HIS194

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PGE H 302

Chain	Residue
H	GLN39
H	THR40
H	PRO41
H	LYS43
H	VAL93
H	GOL305
H	HOH460
H	HOH485
L	GLN43

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PGE H 303

Chain	Residue
H	THR50
H	HOH402
H	HOH466
H	HOH475
H	HOH492
K	GLU11
K	ARG34
K	PHE35
K	HOH113
L	GLN101

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE H 304

Chain	Residue
H	ASN31
H	TYR32
H	HOH406
K	GLU11
K	ASN26
K	THR29
K	HOH115
K	HOH118

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 305

Chain	Residue
H	PRO41
H	THR91
H	THR116
H	THR118
H	GLU156
H	PGE302
H	HOH454

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL H 306

Chain	Residue
H	TYR95
H	GLN113
H	GOL307
L	SER48
L	HOH580

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 307

Chain	Residue
H	GLY114
H	THR115
H	THR116
H	PRO157
H	GOL306
H	HOH446
H	HOH502

---

Functional Information from PROSITE/UniProt

site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FkyGGClgnmnnFetleeC

Chain	Residue	Details
K	PHE35-CYS53

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH

Chain	Residue	Details
H	TYR202-HIS208
L	TYR197-HIS203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Domain: {"description":"BPTI/Kunitz inhibitor 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Reactive bond"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19017259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8639592","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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