4DON

Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Bromodomain-containing protein 4	polymer	145	17225.7	1	UniProt (O60885) Pfam (PF00439)	Homo sapiens (human)	Protein HUNK1
2	B (A)	3-methyl-3,4-dihydroquinazolin-2(1H)-one	non-polymer		162.2	1	Chemie (3PF)
3	C (A)	water	water		18.0	129	Chemie (HOH)

Sequence modifications

A: 44 - 166 (UniProt: O60885)

PDB	External Database	Details
Met 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
His 28	-	expression tag
Ser 29	-	expression tag
Ser 30	-	expression tag
Gly 31	-	expression tag
Val 32	-	expression tag
Asp 33	-	expression tag
Leu 34	-	expression tag
Gly 35	-	expression tag
Thr 36	-	expression tag
Glu 37	-	expression tag
Asn 38	-	expression tag
Leu 39	-	expression tag
Tyr 40	-	expression tag
Phe 41	-	expression tag
Gln 42	-	expression tag
Met 43	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	17225.7
Non-Polymers*	Number of molecules	1
	Total formula weight	162.2
All*	Total formula weight	17387.9

*Water molecules are not included.