4DO0
Crystal Structure of human PHF8 in complex with Daminozide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone lysine demethylase PHF8 | polymer | 374 | 43401.5 | 1 | UniProt (Q9UPP1) Pfam (PF02373) Pfam (PF17811) | Homo sapiens (human) | PHD finger protein 8 |
| 2 | B (A) | DAMINOZIDE | non-polymer | 160.2 | 1 | Chemie (DZA) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E, F, G, H... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | J, L, M (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | K, N (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 7 | O (A) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 79 - 447 (UniProt: Q9UPP1)
| PDB | External Database | Details |
|---|---|---|
| Tyr 74 | - | expression tag |
| Phe 75 | - | expression tag |
| Gln 76 | - | expression tag |
| Ser 77 | - | expression tag |
| Met 78 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43401.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1106.3 | |
| All* | Total formula weight | 44507.8 |
