4DN5
Crystal Structure of NF-kB-inducing Kinase (NIK)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase kinase kinase 14 | polymer | 356 | 39173.7 | 2 | UniProt (Q99558) Pfam (PF00069) In PDB | Homo sapiens (human) | NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK |
| 2 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 5 | A, B | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 2 | Chemie (AGS) | |||
| 6 | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, B: 330 - 680 (UniProt: Q99558)
| PDB | External Database | Details |
|---|---|---|
| Gly 325 | - | expression tag |
| Ala 326 | - | expression tag |
| Met 327 | - | expression tag |
| Gly 328 | - | expression tag |
| Ser 329 | - | expression tag |
| Asp 549 | Ser 549 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78347.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1559.6 | |
| All* | Total formula weight | 79907.0 |
