4DL5
Human DNA polymerase eta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase eta | polymer | 435 | 48617.7 | 1 | UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799) | Homo sapiens (human) | RAD30 homolog A, Xeroderma pigmentosum variant type protein |
| 2 | B (T) | DNA (5'-D(*TP*AP*CP*GP*GP*TP*CP*AP*CP*AP*CP*T)-3') | polymer | 12 | 3622.4 | 1 | |||
| 3 | C (P) | DNA (5'-D(P*TP*AP*GP*TP*GP*TP*GP*AP*C)-3') | polymer | 9 | 2770.8 | 1 | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F (A) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine | non-polymer | 466.2 | 1 | Chemie (0KX) | |||
| 6 | G (T) | Cisplatin | non-polymer | 300.0 | 1 | Chemie (CPT) |
Sequence modifications
A: 1 - 432 (UniProt: Q9Y253)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 55010.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 814.8 | |
| All* | Total formula weight | 55825.7 |
