4DL5

Human DNA polymerase eta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2).

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 501

Chain	Residue
A	ASP13
A	MET14
A	ASP115
A	MG502
A	0KX503
P	DC9

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	GLU116
A	MG501
A	0KX503
P	DA8
P	DC9
A	ASP13
A	SER113
A	ASP115

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0KX A 503

Chain	Residue
A	ASP13
A	MET14
A	ASP15
A	CYS16
A	PHE17
A	PHE18
A	ILE48
A	ALA49
A	TYR52
A	ARG55
A	ARG61
A	ASP115
A	LYS231
A	MG501
A	MG502
P	DA8
P	DC9
T	DG4
T	DG5

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CPT T 101

Chain	Residue
P	DA8
T	DG4
T	DG5
T	DT6
T	DC7

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KFO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27284197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---