4DKJ

CpG specific methyltransferase in complex with target DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cytosine-specific methyltransferase	polymer	403	47310.1	1	UniProt (Q8EVR5) Pfam (PF00145)	Mycoplasma penetrans
2	B (B)	DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(C37)P*GP*CP*TP*GP*AP*A)-3')	polymer	14	4267.8	1
3	C (C)	DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3')	polymer	14	4325.8	1
4	D (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
5	E (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
6	F, G, H (A, B, C)	water	water		18.0	267	Chemie (HOH)

Sequence modifications

A: 1 - 395 (UniProt: Q8EVR5)

PDB	External Database	Details
Arg 68	Gln 68	SEE REMARK 999
Arg 71	Lys 71	SEE REMARK 999
Pro 295	Ser 295	engineered mutation
Leu 396	-	expression tag
Glu 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
His 400	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55903.7
Non-Polymers*	Number of molecules	2
	Total formula weight	476.5
All*	Total formula weight	56380.2

*Water molecules are not included.