4DG4
Human mesotrypsin-S39Y complexed with bovine pancreatic trypsin inhibitor (BPTI)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, B, D, G) | PRSS3 protein | polymer | 224 | 24333.6 | 4 | UniProt (Q8N2U3) Pfam (PF00089) UniProt (by SIFTS) (P35030) | Homo sapiens (human) | |
| 2 | B, D, F, H (E, C, F, H) | Pancreatic trypsin inhibitor | polymer | 58 | 6527.6 | 4 | UniProt (P00974) Pfam (PF00014) | Bos taurus (domestic cattle) | Aprotinin, Basic protease inhibitor, BPI, BPTI |
| 3 | AA, BA, CA, DA, EA... (G, H, A, E, B...) | SULFATE ION | non-polymer | 96.1 | 24 | Chemie (SO4) | |||
| 4 | L (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | HA, IA, JA, KA, LA... (A, E, B, C, D...) | water | water | 18.0 | 1315 | Chemie (HOH) |
Sequence modifications
A, B, D, G: 16 - 246 (UniProt: Q8N2U3)
| PDB | External Database | Details |
|---|---|---|
| Tyr 39 | Ser 49 | engineered mutation |
| Ala 195 | Ser 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 123444.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2345.6 | |
| All* | Total formula weight | 125790.1 |
