4DFX

Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	E	cAMP-dependent protein kinase catalytic subunit alpha	polymer	350	40711.3	1	UniProt (P05132) Pfam (PF00069) In PDB	Mus musculus (mouse)	PKA C-alpha
2	I	cAMP-dependent protein kinase inhibitor alpha	polymer	20	2199.4	1	UniProt (P63248) In PDB	Mus musculus	PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform
3	E	MYRISTIC ACID	non-polymer		228.4	1	Chemie (MYR)
4	E	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
5	E	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	E	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
7		water	water		18.0	453	Chemie (HOH)

Sequence modifications

E: 1 - 350 (UniProt: P05132)

PDB	External Database	Details
Cys 7	Lys 8	ENGINEERED MUTATION

I: 5 - 24 (UniProt: P63248)

PDB	External Database	Details
Ala 20	Asn 21	ENGINEERED MUTATION
Ser 21	Ala 22	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42910.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1059.5
All*	Total formula weight	43970.1

*Water molecules are not included.