4DFX
Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 350 | 40711.3 | 1 | UniProt (P05132) Pfam (PF00069) | Mus musculus (mouse) | PKA C-alpha |
| 2 | B (I) | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2199.4 | 1 | UniProt (P63248) | Mus musculus | PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform |
| 3 | C (E) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) PubChem (11005) | |||
| 4 | D (E) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) PubChem (4795) PubChem (33113) PubChem (445863) PubChem (6102784) PubChem (9543492) PubChem (14188278) PubChem (16058657) PubChem (23639785) PubChem (24794410) PubChem (44462678) PubChem (46926537) PubChem (54765332) PubChem (60063697) PubChem (66575078) PubChem (89688694) PubChem (92436779) PubChem (93005803) | |||
| 5 | E, F (E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | G, H, I (E) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 7 | J, K (E, I) | water | water | 18.0 | 453 | Chemie (HOH) |
Sequence modifications
E: 1 - 350 (UniProt: P05132)
I: 5 - 24 (UniProt: P63248)
| PDB | External Database | Details |
|---|---|---|
| Cys 7 | Lys 8 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 20 | Asn 21 | engineered mutation |
| Ser 21 | Ala 22 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42910.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1059.5 | |
| All* | Total formula weight | 43970.1 |
