4D9R
Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Complement factor D | polymer | 228 | 24438.8 | 2 | UniProt (P00746) Pfam (PF00089) In PDB | Homo sapiens (human) | Adipsin, C3 convertase activator, Properdin factor D |
2 | L, D | Fab light chain | polymer | 214 | 23235.7 | 2 | UniProt (P01834) Pfam (PF07654) In PDB | Homo sapiens (human) | |
3 | H, E | Fab heavy chain | polymer | 218 | 23189.9 | 2 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (human) | |
4 | D | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
L, D: 1 - 104 (PDB: 4D9R)
L, D: 109 - 214 (UniProt: P01834)
H, E: 1 - 116 (PDB: 4D9R)
H, E: 122 - 224 (UniProt: P01857)
L, D: 109 - 214 (UniProt: P01834)
PDB | External Database | Details |
---|---|---|
Glu 105 | - | linker |
Ile 106 | - | linker |
Lys 107 | - | linker |
Arg 108 | - | linker |
H, E: 122 - 224 (UniProt: P01857)
PDB | External Database | Details |
---|---|---|
Val 117 | - | linker |
Thr 118 | - | linker |
Val 119 | - | linker |
Ser 120 | - | linker |
Ser 121 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 141728.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 70.9 | |
All* | Total formula weight | 141799.7 |