4D9R
Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | Complement factor D | polymer | 228 | 24438.8 | 2 | UniProt (P00746) Pfam (PF00089) | Homo sapiens (human) | Adipsin, C3 convertase activator, Properdin factor D |
| 2 | B, F (L, D) | Fab light chain | polymer | 214 | 23235.7 | 2 | UniProt (P01834) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C, E (H, E) | Fab heavy chain | polymer | 218 | 23189.9 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | |
| 4 | G, H (D) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I, J, K, L, M... (A, L, H, B, E...) | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
L, D: 1 - 104 (PDB: 4D9R)
L, D: 109 - 214 (UniProt: P01834)
H, E: 1 - 116 (PDB: 4D9R)
H, E: 122 - 224 (UniProt: P01857)
L, D: 109 - 214 (UniProt: P01834)
| PDB | External Database | Details |
|---|---|---|
| Glu 105 | - | linker |
| Ile 106 | - | linker |
| Lys 107 | - | linker |
| Arg 108 | - | linker |
H, E: 122 - 224 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Val 117 | - | linker |
| Thr 118 | - | linker |
| Val 119 | - | linker |
| Ser 120 | - | linker |
| Ser 121 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 141728.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 70.9 | |
| All* | Total formula weight | 141799.7 |
