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4D9R

Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0008236molecular_functionserine-type peptidase activity
A0009617biological_processresponse to bacterium
A0031093cellular_componentplatelet alpha granule lumen
A0034774cellular_componentsecretory granule lumen
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
B0004252molecular_functionserine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0006956biological_processcomplement activation
B0006957biological_processcomplement activation, alternative pathway
B0008236molecular_functionserine-type peptidase activity
B0009617biological_processresponse to bacterium
B0031093cellular_componentplatelet alpha granule lumen
B0034774cellular_componentsecretory granule lumen
B0070062cellular_componentextracellular exosome
B1904813cellular_componentficolin-1-rich granule lumen
D0002250biological_processadaptive immune response
D0003823molecular_functionantigen binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0016064biological_processimmunoglobulin mediated immune response
D0019814cellular_componentimmunoglobulin complex
D0050853biological_processB cell receptor signaling pathway
D0070062cellular_componentextracellular exosome
D0071735cellular_componentIgG immunoglobulin complex
D0071738cellular_componentIgD immunoglobulin complex
D0071742cellular_componentIgE immunoglobulin complex
D0071745cellular_componentIgA immunoglobulin complex
D0071753cellular_componentIgM immunoglobulin complex
D0072562cellular_componentblood microparticle
L0002250biological_processadaptive immune response
L0003823molecular_functionantigen binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0005886cellular_componentplasma membrane
L0006955biological_processimmune response
L0016064biological_processimmunoglobulin mediated immune response
L0019814cellular_componentimmunoglobulin complex
L0050853biological_processB cell receptor signaling pathway
L0070062cellular_componentextracellular exosome
L0071735cellular_componentIgG immunoglobulin complex
L0071738cellular_componentIgD immunoglobulin complex
L0071742cellular_componentIgE immunoglobulin complex
L0071745cellular_componentIgA immunoglobulin complex
L0071753cellular_componentIgM immunoglobulin complex
L0072562cellular_componentblood microparticle
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL D 301
ChainResidue
DARG55
DHOH408
EASN109

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL D 302
ChainResidue
DASP92

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
ChainResidueDetails
AASP189-VAL200

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR192-HIS198
HTYR202-HIS208

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195
BHIS57
BASP102
BSER195

224931

PDB entries from 2024-09-11

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