4D2T
Structure of MELK in complex with inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | polymer | 356 | 40876.3 | 4 | UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) In PDB | HOMO SAPIENS (HUMAN) | HMELK, PROTEIN KINASE EG3, PEG3 KINASE, PROTEIN KINASE PK38, HPK38, TYROSINE-PROTEIN KINASE MELK, HMELK, PROTEIN KINASE EG3, PEG3 KINASE, PROTEIN KINASE PK38 , HPK38, TYROSINE-PROTEIN KINASE MELK, MELK |
2 | A, B, C, D | 3-[2-(phenylcarbamoyl)-5-(1H-pyrazol-4-yl)phenoxy]propan-1-aminium | non-polymer | 337.4 | 4 | Chemie (3I7) | |||
3 | water | water | 18.0 | 396 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 336 (UniProt: Q14680)
PDB | External Database | Details |
---|---|---|
Met -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Ala 167 | Thr 167 | engineered mutation |
Ala 171 | Ser 171 | engineered mutation |
Thr 213 | Asn 213 | engineered mutation |
Ala 214 | Val 214 | engineered mutation |
Ala 215 | Met 215 | engineered mutation |
Val 218 | Tyr 218 | engineered mutation |
Ala 219 | Lys 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 163505.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1349.6 | |
All* | Total formula weight | 164854.7 |