4CY2

Crystal structure of the KANSL1-WDR5-KANSL2 complex.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	WD REPEAT-CONTAINING PROTEIN 5	polymer	316	34620.3	1	UniProt (P61964) Pfam (PF00400)	HOMO SAPIENS (HUMAN)	BMP2-INDUCED 3-KB GENE PROTEIN
2	B (C)	KAT8 REGULATORY NSL COMPLEX SUBUNIT 2	polymer	13	1430.4	1	UniProt (Q9H9L4)	HOMO SAPIENS	KANSL2, NSL COMPLEX PROTEIN NSL2, NON-SPECIFIC LETHAL 2 HOMOLOG
3	C (D)	KAT8 REGULATORY NSL COMPLEX SUBUNIT 1	polymer	15	1610.8	1	UniProt (Q7Z3B3)	HOMO SAPIENS	KANSL1, MLL1/MLL COMPLEX SUBUNIT KANSL1, MSL1 HOMOLOG 1, HMSL1V1, NSL COMPLEX PROTEIN NSL1, NON-SPECIFIC LETHAL 1 HOMOLOG
4	D, E (A, D)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A: 23 - 334 (UniProt: P61964)

PDB	External Database	Details
Gly 19	-	expression tag
Ala 20	-	expression tag
Met 21	-	expression tag
Gly 22	-	expression tag

C: 406 - 417 (UniProt: Q9H9L4)

PDB	External Database	Details
Tyr 405	-	expression tag

D: 585 - 598 (UniProt: Q7Z3B3)

PDB	External Database	Details
Tyr 599	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	37661.6
All*	Total formula weight	37661.6

*Water molecules are not included.