4CY1
Crystal structure of the KANSL1-WDR5 complex.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | WD REPEAT-CONTAINING PROTEIN 5 | polymer | 316 | 34620.3 | 2 | UniProt (P61964) Pfam (PF00400) | HOMO SAPIENS (HUMAN) | BMP2-INDUCED 3-KB GENE PROTEIN |
| 2 | C, D (C, D) | KAT8 REGULATORY NSL COMPLEX SUBUNIT 1 | polymer | 15 | 1610.8 | 2 | UniProt (Q7Z3B3) | HOMO SAPIENS | KANSL1, MLL1/MLL COMPLEX SUBUNIT KANSL1, MSL1 HOMOLOG 1, HMSL1V1, NSL COMPLEX PROTEIN NSL1, NON-SPECIFIC LETHAL 1 HOMOLOG |
| 3 | E, F, G (A, B, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 321 | Chemie (HOH) |
Sequence modifications
A, B: 23 - 334 (UniProt: P61964)
C, D: 585 - 598 (UniProt: Q7Z3B3)
| PDB | External Database | Details |
|---|---|---|
| Met 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Gly 335 | - | expression tag |
| Ala 336 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Tyr 599 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 72462.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 72738.5 |
