4CN2

Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Ramp2 Response Element

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	5'-D(*TP*GP*AP*GP*TP*TP*CP*AP*AP*GP*GP*GP*TP*DC *AP*AP*TP)-3'	polymer	17	5266.4	1		HOMO SAPIENS
2	B (B)	5'-D(*AP*TP*TP*GP*AP*CP*CP*CP*TP*TP*GP*AP*AP*DC *TP*CP*AP)-3'	polymer	17	5146.4	1		HOMO SAPIENS
3	C, D (C, D)	RETINOIC ACID RECEPTOR RXR-ALPHA	polymer	87	10262.9	2	UniProt (P19793) Pfam (PF00105)	HOMO SAPIENS (HUMAN)	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 1, RETINOID X RECEPTOR ALPHA, RETINOID X RECEPTOR
4	E, F, G, L, M... (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	7	Chemie (MG)
5	H, I, O, P (C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	J (C)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
7	K, Q, R, S (C, D)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
8	U, V, W, X (A, B, C, D)	water	water		18.0	156	Chemie (HOH)

Sequence modifications

C, D: 130 - 212 (UniProt: P19793)

PDB	External Database	Details
Gly 126	-	expression tag
Ser 127	-	expression tag
His 128	-	expression tag
Met 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	30938.6
Non-Polymers*	Number of molecules	16
	Total formula weight	768.8
All*	Total formula weight	31707.5

*Water molecules are not included.